Telomere Science Library

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about the Nobel-Prize Winning Science of Telomere Biology

The effect on melanoma risk of genes previously associated with telomere length.

Authors: Mark M MM. Iles, D Timothy DT. Bishop, John C JC. Taylor, Nicholas K NK. Hayward, Myriam M. Brossard, Anne E AE. Cust, Alison M AM. Dunning, Jeffrey E JE. Lee, Eric K EK. Moses, Lars A LA. Akslen, Per A PA. Andresen, Marie-Françoise MF. Avril, Esther E. Azizi, Giovanna Bianchi GB. Scarrà, Kevin M KM. Brown, Tadeusz T. Dębniak, David E DE. Elder, Eitan E. Friedman, Paola P. Ghiorzo, Elizabeth M EM. Gillanders, Alisa M AM. Goldstein, Nelleke A NA. Gruis, Johan J. Hansson, Mark M. Harland, Per P. Helsing, Marko M. Hočevar, Veronica V. Höiom, Christian C. Ingvar, Peter A PA. Kanetsky, Maria Teresa MT. Landi, Julie J. Lang, G Mark GM. Lathrop, Jan J. Lubiński, Rona M RM. Mackie, Nicholas G NG. Martin, Anders A. Molven, Grant W GW. Montgomery, Srdjan S. Novaković, Håkan H. Olsson, Susana S. Puig, Joan Anton JA. Puig-Butille, Graham L GL. Radford-Smith, Juliette J. Randerson-Moor, Nienke N. van der Stoep, Remco R. van Doorn, David C DC. Whiteman, Stuart S. MacGregor, Karen A KA. Pooley, Sarah V SV. Ward, Graham J GJ. Mann, Christopher I CI. Amos, Paul D P PD. Pharoah, Florence F. Demenais, Matthew H MH. Law, Julia A JA. Newton Bishop, Jennifer H JH. Barrett
Published: 09/17/2014, Journal of the National Cancer Institute


Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92x10(-9), two-sided) with melanoma risk. This demonstrates that the previously observed association between longer telomere length and increased melanoma risk is not attributable to confounding via shared environmental effects (such as ultraviolet exposure) or reverse causality. We provide the first proof that multiple germline genetic determinants of telomere length influence cancer risk.

© The Author 2014. Published by Oxford University Press.
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