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Replication of the results of genome-wide and candidate gene association studies on telomere length in a Korean population.

telomere length

Authors: Sook Kyung SK. Do, Seung Soo SS. Yoo, Yi Young YY. Choi, Jin Eun JE. Choi, Hyo-Sung HS. Jeon, Won Kee WK. Lee, Shin Yup SY. Lee, Jaehee J. Lee, Seung Ick SI. Cha, Chang Ho CH. Kim, Jae Yong JY. Park
Published: 08/27/2015, The Korean journal of internal medicine

Background/aims

A number of genome-wide and candidate gene association studies have identified polymorphisms associated with telomere length in Caucasian populations. This study was conducted to determine the impacts of 17 polymorphisms identified in Caucasians on telomere length in a Korean population.

Methods

Ninety-four healthy individuals were enrolled in this study. Relative telomere length of chromosomes from peripheral blood samples was measured using quantitative polymerase chain reaction.

Results

Two polymorphisms, rs10936599 of MYNN and rs412658 of ZNF676, were found to be associated w ith telomere length (under dominant model, p = 0.04; under recessive model, p = 0.001). Three polymorphisms, rs2853669, rs7705526, and rs2736108, at the TERT locus were also associated with telomere length (under recessive model, p = 0.01, p = 0.02, and p = 0.01, respectively). The genotypes of the five polymorphisms associated with short telomere length were considered bad genotypes; telomere length was significantly decreased with increasing number of bad genotypes (p= 1.7 × 10(-5)).

Conclusions

We have identified polymorphisms associated with telomere length in a Korean population.

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