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Modern genome editing meets telomeres: the many functions of TPP1.

Authors: Jan J. Karlseder
Published: 09/04/2014, Genes & development


The telomeric complex has been analyzed in detail for its role in regulating telomere protection and telomere length. Now, modern genome-editing techniques in human embryonic stem cells reveal TPP1 as the essential recruitment factor for telomerase, with additional functions in telomerase activation and definition of telomere length homeostasis.

© 2014 Karlseder; Published by Cold Spring Harbor Laboratory Press.
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