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Individual telomere length decay in patients with spondyloarthritis.

Authors: María M. Tamayo, Sonia S. Pértega, Alejandro A. Mosquera, Montserrat M. Rodríguez, Francisco J FJ. Blanco, José Luis JL. Fernández-Sueiro, Jaime J. Gosálvez, José Luis JL. Fernández
Published: 04/24/2014, Mutation research


Telomere length was sequentially determined in peripheral blood leukocytes (PBL) from patients with ankylosing spondylitis (AS; n = 44) and psoriatic arthritis (PsA; n = 42) followed through 2.93 ± 0.99 years, using a quantitative PCR (qPCR) assay. The initial telomere size from PsA patients was higher than those with cutaneous psoriasis only (n = 53), possibly due to the inflammatory condition. The qPCR assay was sensitive enough to evidence a significant telomere length shortening in PBL from practically all subjects and PsA patients showed a higher rate of loss of telomere sequence than patients with AS during the follow-up time.

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