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Homocysteine Levels Are not Related to Telomere Length in Cord Blood Leukocytes of Newborns.

Authors: Rachel G RG. Sinkey, Hamisu M HM. Salihu, Lindsey M LM. King, Arnut A. Paothong, Adetola A. Louis-Jacques, Anupam A. Pradhan, Karen L KL. Bruder, Roger R. Zoorob, Erin E. Siegel, Bridget B. Riggs, Valerie E VE. Whiteman
Published: 12/21/2015, American journal of perinatology


Objective Elevated homocysteine (HC) levels and/or shortened telomere length (TL) are associated with adverse medical conditions. Our objective is to investigate the relationship between HC and TL in cord blood leukocytes of newborns. Study Design This is a nested study from a prospective cohort from 2011 to 2012 in pregnant women admitted for delivery at a university-affiliated hospital. Cord blood was collected at delivery and genomic DNA was analyzed using quantitative PCR. The telomere-to-single copy gene ratio method was employed to quantify TL. Newborn HC levels were measured. generalized linear regression modeling (GLM) and bootstrap statistical analyses were performed. Results Seventy-seven maternal-fetal dyads with a mean gestational age of 39 weeks were included. The distribution of the coefficient of homocysteine showed most values greater than zero demonstrating that homocysteine had a positive relationship with TL. In 915 of 10,000 (9.15%) iterations, the p-value was < 0.05 demonstrating a positive effect. Conclusion Increasing newborn concentrations of HC are not associated with decreasing TL. Larger, prospective studies are needed to confirm these findings and long-term implications.

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