Telomere Science Library

Publications, Presentations, and Videos
about the Nobel-Prize Winning Science of Telomere Biology

Estimating telomere length from whole genome sequence data.

Authors: Zhihao Z. Ding, Massimo M. Mangino, Abraham A. Aviv, Tim T. Spector, Richard R. Durbin
Published: 03/07/2014, Nucleic acids research


Telomeres play a key role in replicative ageing and undergo age-dependent attrition in vivo. Here, we report a novel method, TelSeq, to measure average telomere length from whole genome or exome shotgun sequence data. In 260 leukocyte samples, we show that TelSeq results correlate with Southern blot measurements of the mean length of terminal restriction fragments (mTRFs) and display age-dependent attrition comparably well as mTRFs.

© The Author(s) 2014. Published by Oxford University Press [on behalf of insert name of society].
PubMed Full Text