Telomere Science Library

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Turning telomerase into a Jekyll and Hyde case?

Authors: Raymund J RJ. Wellinger
Published: 01/13/2015, Cancer discovery


It may be possible to coerce telomerase to incorporate modified guanine nucleotides into telomeric repeat DNA, thereby seriously compromising the functionality of the telomeres. Thus, a guanine analogue such as 6-thio-dG could turn active telomerase into a chromosome de-protecting enzyme, the opposite of what it is normally, namely a chromosome-protecting enzyme.

©2015 American Association for Cancer Research.
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