Telomere Science Library

Publications, Presentations, and Videos
about the Nobel-Prize Winning Science of Telomere Biology

The Telomeric Protein TRF2 Regulates Angiogenesis by Binding and Activating the PDGFRβ Promoter.

Authors: Mounir M. El Maï, Kay-Dietrich KD. Wagner, Jean-François JF. Michiels, Damien D. Ambrosetti, Arnaud A. Borderie, Sandrine S. Destree, Valerie V. Renault, Nadir N. Djerbi, Marie-Josèphe MJ. Giraud-Panis, Eric E. Gilson, Nicole N. Wagner
Published: 10/23/2014, Cell reports


Telomeric repeat binding factor 2 (TRF2), which plays a central role in telomere capping, is frequently increased in human tumors. We reveal here that TRF2 is expressed in the vasculature of most human cancer types, where it colocalizes with the Wilms' tumor suppressor WT1. We further show that TRF2 is a transcriptional target of WT1 and is required for proliferation, migration, and tube formation of endothelial cells. These angiogenic effects of TRF2 are uncoupled from its function in telomere capping. Instead, TRF2 binds and transactivates the promoter of the angiogenic tyrosine kinase platelet-derived growth factor receptor β (PDGFRβ). These findings reveal an unexpected role of TRF2 in neoangiogenesis and delineate a distinct function of TRF2 as a transcriptional regulator.

Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.
PubMed Full Text