Telomere Science Library

Publications, Presentations, and Videos
about the Nobel-Prize Winning Science of Telomere Biology

Targeting cathepsin B by cycloastragenol enhances antitumor immunity of CD8 T cells via inhibiting MHC-I degradation

Authors: Guoliang Deng, Lisha Zhou, Binglin Wang, Xiaofan Sun, Qinchang Zhang, Hongqi Chen, Ning Wan, Hui Ye, Xiaoqi Wu, Dongdong Sun, Yang Sun, Haibo Cheng
Published: 10/2022, Journal for Immunotherapy for Cancer


The loss of tumor antigens and depletion of CD8 T cells caused by the PD-1/PD-L1 pathway are important factors for tumor immune escape. In recent years, there has been increasing research on traditional Chinese medicine in tumor treatment. Cycloastragenol (CAG), an effective active molecule in Astragalus membranaceus, has been found to have antiviral, anti-aging, anti-inflammatory, and other functions. However, its antitumor effect and mechanism are not clear.

PubMed Full Text