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High-density array comparative genomic hybridization detects novel copy number alterations in gastric adenocarcinoma.

cancer

genetics

Authors: Aline Damasceno AD. Seabra, Taíssa Maíra Thomaz TM. Araújo, Fernando Augusto Rodrigues FA. Mello Junior, Diego D. Di Felipe Ávila Alcântara, Amanda Paiva AP. De Barros, Paulo Pimentel PP. De Assumpção, Raquel Carvalho RC. Montenegro, Adriana Costa AC. Guimarães, Samia S. Demachki, Rommel Mario Rodríguez RM. Burbano, André Salim AS. Khayat
Published: 11/04/2014, Anticancer research

Aim

To investigate frequent quantitative alterations of intestinal-type gastric adenocarcinoma.

Materials And Methods

We analyzed genome-wide DNA copy numbers of 22 samples and using CytoScan® HD Array.

Results

We identified 22 gene alterations that to the best of our knowledge have not been described for gastric cancer, including of v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 (ERBB4), SRY (sex determining region Y)-box 6 (SOX6), regulator of telomere elongation helicase 1 (RTEL1) and UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 (B4GALT5). The most significant alterations related to peritoneal invasion involved the regions 13q21.1 (gain) and 15q15.1, 17q23.1, 19q13.2 and 20q11.22 (loss of heterozygozity; LOH), where we found LOH of erythrocyte membrane protein band 4.1-like 1 (EPB41L1) gene. In relation to early age of onset, the most significant alterations were gains in the regions Xq26 and Xp22.31 and a loss in the region 11p15.4.

Conclusion

These quantitative changes may play a role in the development of this type of neoplasia and may be used as markers in evaluating poor prognosis, as well as act as potential therapeutic targets for gastric cancer.

Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.
PubMed