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about the Nobel-Prize Winning Science of Telomere Biology

Direct observation of the dual-switching behaviors corresponding to the state transition in a DNA nanoframe.

Authors: Yangyang Y. Yang, Masayuki M. Endo, Yuki Y. Suzuki, Kumi K. Hidaka, Hiroshi H. Sugiyama
Published: 03/25/2014, Chemical communications (Cambridge, England)


To create a nanoscale dual switch, two responsive DNA motifs, azobenzene-modified DNAs and G-telomeric repeat sequences, were introduced together into the nanoframe system. The dual-switching behaviors controlled by photoirradiation and K(+) were successfully visualized in real time by high-speed atomic force microscopy.

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