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Charting the "Splice" Routes to MDS.

Authors: Esther A EA. Obeng, Benjamin L BL. Ebert
Published: 05/13/2015, Cancer cell


Mutations in components of the 3' mRNA splicing machinery are found in almost 50% of myelodysplastic syndrome (MDS) cases. In this issue of Cancer Cell, Kim and colleagues, Colla and colleagues, and Shirai and colleagues report on the impact of mutated or dysregulated splicing factors to hematopoiesis, mRNA splicing, and MDS pathogenesis.

Copyright © 2015 Elsevier Inc. All rights reserved.
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