Telomere Science Library

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about the Nobel-Prize Winning Science of Telomere Biology

[Advances of Research on Ataxia Telangiectasia Mutated Gene and Risk Factors of Cardiovascular Disease].

Authors: Xiang X. Ding, Yi Y. Ding, Jirong J. Yue, Hengyi H. Xiao, Birong B. Dong
Published: 07/27/2015, Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi


Cardiovascular disease is a severe threat to human health and life. Among many risk factors of cardiovascular disease, genetic or gene-based ones are drawing more and more attention in recent years. Accumulated evidence has demonstrated that the loss or mutation of ataxia telangiectasia mutated (ATM) gene can result in DNA damage repair dysfunctions, telomere shortening, decreased antioxidant capacity, insulin resistance, increased lipid levels, etc., and thus can promote the occurrence of cardiovascular risk factors, such as aging, atherosclerosis and metabolic syndrome. In this review, we discusses the possible mechanisms between ATM gene and cardiovascular risk factors, which could be helpful to the related research and clinical application.