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Zhengwei Xie, Kyle A. Jay, Hao Li, Elizabeth H. Blackburn Telomerase is required for long-term telomere maintenance and protection. Using single budding yeast mother cell analyses we found that, even early after telomerase inactivation (ETI), yeast mother cells show transient DNA damage response (DDR) episodes, stochastically altered cell-cycle dynamics, and accelerated...

American Medical Association Telomeres are long (TTAGGG) tandem nucleotide repeats and an associated protein complex located at chromosome ends that are essential for maintaining chromosomal stability. Telomeres shorten with each cell division due to the inability of DNA polymerases to completely replicate the chromosome ends. Consequently, telomeres are markers of cellular replicative capacity, cellular senescence, and aging. Read...

Siegl-Cachedenier I, Flores I, Klatt P, Blasco MA. J Cell Biol. ;179(2):277-90. Organ homeostasis and organismal survival are related to the ability of stem cells to sustain tissue regeneration. As a consequence of accelerated telomere shortening, telomerase-deficient mice show defective tissue regeneration and premature death. This suggests a direct impact of...

Aging Cell Mirabello L, Huang WY, Wong JY, Chatterjee N, Reding D, Crawford ED, De Vivo I, Hayes RB, Savage SA.Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.Telomeres consist of nucleotide repeats and a protein complex...

Dale E. Rae1, 7 , Alban Vignaud2, 3, Gillian S. Butler-Browne2, 3, Lars-Eric Thornell4, Colin Sinclair-Smith5, E. Wayne Derman1, Mike I. Lambert1 and Malcolm Collins6, 1 (1)UCT/MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa(2)Institut de Myologie, UPMC Univ Paris 06, UMR-S 974, 75013 Paris, France(3)Institut de...

By Gretchen Reynolds, New York Times Health Blog The sedentary older subjects had telomeres that were on average 40 percent shorter than in the sedentary young subjects, suggesting that the older subjects’ cells were, like them, aging. The runners, on the other hand, had remarkably youthful telomeres, a...

Mech Ageing Dev. 2010 Feb;131(2):165-167. Epub 2010 Jan 12. Larocca TJ, Seals DR, Pierce GL.Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA.Telomere length (TL), a measure of replicative senescence, decreases with aging, but the factors involved are incompletely understood. To determine if age-associated reductions in...

Baerlocher GM, Vulto I, de Jong G, Lansdorp PM Terry Fox Laboratory, British Columbia Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia, V5Z 1L3, Canada. . Nat Protoc. 2006;1(5):2365-76. Telomeres have emerged as crucial cellular elements in aging and various diseases including cancer. To measure the...

Rita Effros Presentation Summary for SENS (Aubrey de Grey) Conference 6 Sept 2007R.B. Effros David Geffen School of Medicine at UCLA, Department of Pathology and Laboratory Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095-1732, USA The immune system plays a role not only in controlling infections, but...

Njajou OT, Hsueh WC, Blackburn EH, Newman AB, Wu SH, Li R, Simonsick EM, Harris TM, Cummings SR, Cawthon RM; for the Health ABC study Although Telomere Length (TL) is known to play a critical role in cellular senescence, the relationship of TL to aging and longevity in humans is...

Maria A Blasco, Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre, Madrid, Spain. Published online 17 September 2007/ Nature Chemical Biology 2007.38 Telomere shortening occurs concomitant with organismal aging, and it is accelerated in the context of human diseases associated with mutations in telomerase, such as some cases...

Guan JZ, Maeda T, Sugano M, Oyama J, Higuchi Y, Makino N. Mol Cell Biochem. 2007 Oct;304(1-2):353-60 . Telomeres play a role in cellular aging and they may also contribute to the genetic basis of human aging and longevity. A gradual loss of the telomeric repeat sequences has...

Masayuki Kimura, Jacob v. B. Hjelmborg, Jeffrey P. Gardner, Lise Bathum, Michael Brimacombe, Xiaobin Lu, Lene Christiansen, James W. Vaupel, Abraham Aviv, and Kaare Christensen; American Journal of Epidemiology Advance Access Leukocyte telomere length, representing the mean length of all telomeres in leukocytes, is ostensibly a bioindicator of human aging. The...

Prof Dean Ornish MD, Jue Lin PhD, Jennifer Daubenmier PhD, Gerdi Weidner PhD, Elissa Epel PhD, Colleen Kemp MSN, Mark Jesus M Magbanua PhD, Ruth Marlin MD, Loren Yglecias BA, Prof Peter R Carroll MD and Prof Elizabeth H Blackburn PhD Telomeres are protective DNA-protein complexes at the...

Antonia Tomás-Loba1, Ignacio Flores1, Pablo J. Fernández-Marcos, María L. Cayuela1, Antonio Maraver, Agueda Tejera1, Consuelo Borrás, Ander Matheu, Peter Klatt1, Juana M. Flores, José Viña, Manuel Serrano and Maria A. Blasco1 Telomerase confers limitless proliferative potential to most human cells through its ability to elongate telomeres, the natural...

Sheila A. Stewart - Departments of Cell Biology and Physiology and of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, and Robert A. Weinberg - Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142. Annu Rev Cell Dev Biol. 2006;22:531-57 ...

Barry E. Flanary, Nicole W. Sammons, Cuong Nguyen, Douglas Walker, and Wolfgang J. Streit. March 22, 2007REJUVENATION RESEARCH, Volume 10, Number 1, 2007Advanced age and presence of intracerebral amyloid deposits are known to be major risk factors for development of neurodegeneration in Alzheimer's disease (AD), and both...

H. Jiang, Z. Ju, K.L. Rudolph; Z Gerontol Geriat 40:314-324; 2007 Telomeres form the ends of human chromosomes. Telomeres shorten with each round of cell division and this mechanism limits proliferation of human cells to a finite number of cell divisions by inducing replicative senescence, differentiation, or apoptosis....

Iain P. Nicholson, Elizabeth A. Gault, Christopher G. Foote, Lubna Nasir, David Bennett. The Veterinary Journal, 2007. To determine if the exogenous expression of the human telomerase reverse transcriptase (hTERT) protein can extend the in vitro lifespan of chondrocytes from normal and osteoarthritic canine donors, articular chondrocytes were...