Telomere Science Library

Publications, Presentations, and Videos
about the Nobel-Prize Winning Science of Telomere Biology

telomerase activation

http://www.telomerescience.com/cell-aging-in-relation-to-stress-arousal-and-cardiovascular-disease-risk-factors-23.html
Epel ES, Lin J, Wilhelm FH, Wolkowitz OM, Cawthon R, Adler NE, Dolbier C, Mendes WB, Blackburn EH. Psychoneuroendocrinology. 2006 Apr;31(3):277-87. We previously reported that psychological stress is linked to and possibly accelerates cellular aging, as reflected by lower PBMC telomerase and shortened telomeres. Psychological stress is a ...
http://www.telomerescience.com/telomerase-induction-in-t-cells-a-cure-for-aging-and-disease-27.html
Rita B. Effros, Experimental Gerontology, Volume 42, Issue 5, 416-420. Clinical studies have shown that high proportions of CD8 T cells with the senescent phenotype correlate with several deleterious physiologic outcomes, including poor vaccine responses, bone loss, and increased proinflammatory cytokines. CD8(+)CD28(-) T cells have also been shown ...
http://www.telomerescience.com/telomerase-reverses-epidermal-hair-follicle-stem-cell-defects-and-loss-of-longterm-survival-associated-with-critically-short-telomeres-47.html
Siegl-Cachedenier I, Flores I, Klatt P, Blasco MA. J Cell Biol. ;179(2):277-90. Organ homeostasis and organismal survival are related to the ability of stem cells to sustain tissue regeneration. As a consequence of accelerated telomere shortening, telomerase-deficient mice show defective tissue regeneration and premature death. This suggests a ...
http://www.telomerescience.com/telomerasebased-approaches-to-enhance-immunity-to-viruses-during-ageing-26.html
Rita Effros Presentation Summary for SENS (Aubrey de Grey) Conference 6 Sept 2007 R.B. Effros David Geffen School of Medicine at UCLA, Department of Pathology and Laboratory Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095-1732, USA The immune system plays a role not only in controlling infections, but ...
http://www.telomerescience.com/telomere-and-telomerase-in-stem-cells-52.html
E Hiyama and K Hiyama, British Journal of Cancer 96, 1020-1024. Telomeres, guanine-rich tandem DNA repeats of the chromosomal end, provide chromosomal stability, and cellular replication causes their loss. In somatic cells, the activity of telomerase, a reverse transcriptase that can elongate telomeric repeats, is usually diminished after ...
http://www.telomerescience.com/telomerase-therapeutics-for-degenerative-diseases-53.html
Calvin B. Harley, PhD., Geron Corporation, 230 Constitution Drive, Menlo Park, CA, USA, 94025. Current Molecular Medicine, 2005. Telomerase is active in early embryonic and fetal development but is down-regulated in all human somatic tissues before birth. Since telomerase is virtually absent or only transiently active in normal ...
http://www.telomerescience.com/geron-increases-stake-in-ta-therapeutics-joint-venture-78.html
Geron Corporation (Nasdaq: GERN) and the Biotechnology Research Corporation (BRC) of Hong Kong today announced that Geron has increased its stake in their joint venture entity, TA Therapeutics Limited (TAT), from 50% ownership to 75% ownership. TAT is a Hong Kong company that conducts research and develops therapeutics ...
http://www.telomerescience.com/geron-and-ta-therapeutics-announce-presentation-of-new-data-supporting-utility-of-their-small-molecule-telomerase-activator-tat0002-tat0002-selected-as-lead-compound-for-hivaids-indication-79.html
MENLO PARK, Calif. -- Geron Corporation (Nasdaq:GERN) and TA Therapeutics, Ltd., a joint venture between Geron Corporation and the Biotechnology Research Corporation of Hong Kong (BRC), announced today the presentation of studies demonstrating that their small molecule telomerase activator, TAT0002, enhances the anti-viral activity of CD8 T-cells from HIV/AIDS donors ...
http://www.telomerescience.com/lorealunesco-awards-honor-ucsf-biologist-for-pioneering-research-in-dna-synthesis-76.html
Researcher who Discovered Telomerase’s Role in Aging and Cell Mutation among Five Women Scientists Awarded in Paris NEW YORK, NY - December 6, 2007 - For her pioneering work with telomeres, the protective caps at the ends of chromosomes, and their relation to cell aging and disease, Dr. ...
http://www.telomerescience.com/cnio-scientists-successfully-test-the-first-gene-therapy-against-agingassociated-decline-115.html
  Mouse lifespan extended up to 24 percent with a single treatment. A number of studies have shown that it is possible to lengthen the average life of individuals of many species, including mammals, by acting on specific genes. To date, however, this has meant altering the animals' genes ...
http://www.telomerescience.com/telomereindependent-functions-of-telomerase-in-nuclei-cytoplasm-and-mitochondria-124.html
Ilaria Chiodi and Chiara Mondello* Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, Pavia, Italy Telomerase canonical activity at telomeres prevents telomere shortening, allowing chromosome stability and cellular proliferation. To perform this task, the catalytic subunit (telomerase reverse transcriptase, TERT) of the enzyme works as a reverse transcriptase together ...