Telomere Science Library

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about the Nobel-Prize Winning Science of Telomere Biology

Highly sensitive detection of telomerase using a telomere-triggered isothermal exponential amplification-based DNAzyme biosensor.

Authors: Yan Y. Zhang, Li-juan LJ. Wang, Chun-yang CY. Zhang
Published: 01/09/2014, Chemical communications (Cambridge, England)

Abstract

A telomere-triggered isothermal exponential amplification-based DNAzyme biosensor is developed for highly sensitive detection of telomerase in cancer cells even at the single-cell level. This biosensor can be further applied for the screening of telomerase inhibitors for anticancer drug development.

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